By Stanley T. Crooke

greatly revised and up to date, Antisense Drug expertise: ideas, innovations, and purposes, moment Edition displays the logarithmic development made some time past 4 years of oligonucleotide-based treatments, and, specifically, antisense therapeutics and examine. analyzing classes discovered from the medical trials of first new release medicinal drugs, the booklet evaluates the expertise as a complete and provides new instructions and avenues of study and improvement.

Divided into 5 components, the booklet starts off with an intensive advent to the mechanism of antisense drug motion together with the RNase H mechanism, small RNA silencing pathways, and the aptitude therapeutics of splice switching oligonucleotides. top researchers exhibit the fundamentals of oligonucleotide therapeutics partially by means of delineating medicinal chemistry, pharmacokinetics, and supply routes similar to liposomal formulations for nucleic acid delivery.  half 3 information hybridization established medications and considers the dramatic advances represented via 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA medications. different chemical periods of gear and mechanisms of motion are defined partly 4 with additional discussions on enhancing the second one iteration antisense medicinal drugs. the ultimate half delves deeply into healing purposes. Contributing authors research the possibility of antisense medications for the relief of cardiovascular ailments, metabolic illnesses, inflammatory illnesses, melanoma, neurological issues, and immune modulation.

Presenting a hugely specified, lucid dialogue of the outstanding advances within the box, Antisense Drug know-how: ideas, options, and functions, moment Edition presents the platform for researchers to proceed to aggressively pursue the nice chance represented via this interesting technology.

--This textual content refers back to the Hardcover edition.

Show description

Read Online or Download Antisense Drug Technology: Principles, Strategies, and Applications: Principles, Strategies and Applications PDF

Best biotechnology books

Biotechnology in Comparative Perspective (Routledge Studies in Global Competition)

The biotechnology is a really very important region within the constructed world's economies. This booklet, with contributions from a global array of specialists, explains why biotechnology businesses in numerous international locations focus in a small variety of destinations and what money owed for the luck a few of these businesses then pass directly to have.

Environmental Forensics: Contaminant Specific Guide

Environmental forensics is the applying of clinical suggestions for the aim of deciding upon the resource and age of a contaminant. over the last numerous years, this research has been increasing as a process examine in academia, executive and advertisement markets. the U.S. Environmental safeguard enterprise (EPA), Federal Bureau of research (FBI), and Federal Emergency administration organisation (FEMA) are one of the governmental enterprises that make the most of the learn of environmental forensics to make sure nationwide safeguard and to make sure that businesses are complying with criteria.

Photosynthesis: Structures, Mechanisms, and Applications

To handle the environmental, socioeconomic, and geopolitical concerns linked to expanding worldwide human power intake, applied sciences for using renewable carbon-free or carbon-neutral strength assets needs to be pointed out and built. between renewable resources, solar power is sort of promising because it by myself is enough to meet worldwide human calls for good into the foreseeable destiny.

Plant Biotechnology

Plant biotechnology performs a crucial position in uncomplicated and technologies. it's a clinical method that adapts crops for particular reasons of cross-breeding, extending their transforming into seasons, adjusting peak, color, and texture, and several mechanisms. Plant biotechnology is helping plant breeders to advance plants with particular valuable and fascinating characteristics.

Additional resources for Antisense Drug Technology: Principles, Strategies, and Applications: Principles, Strategies and Applications

Example text

Download PDF sample

Rated 4.78 of 5 – based on 10 votes